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Lack of folate can induce increased secretion of pro-inflammatory factors and impair hepatic lipid metabolism, resulting in hepatic lipid accumulation and fibrosis

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Both genes are essential for producing oleic acid, a lipid that is neuroprotective in rodents (Song et al , 2019), induces lifespan extension (Fang et al , 2016) and prevents polyQ aggregation in worms (Goudeau et al , 2011